Trans-6-(2-(n-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl-

Details Trans-6-(2-(n-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl- Trans-6-(2-(n-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl-

1990-06-19

1992-04-07

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546104, 546159, 546167, 546279, 544322, 544326, 548217, 548374, C07D40504, C07D40506, C07D21538, A61K 3147

Patent

active

051028930

ABSTRACT:
Certain trans-6-[2-(N-heteroaryl-3,5-disubstituted) pyrazol-4-yl)ethyl]- or ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-ones and the corresponding ring-opened acids, esters and N-oxides derived therefrom which are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG CoA reductase) and are thus useful hydrolipidemic or hypocholesterolemic agents. Pharmaceutical compositions containing such compounds, and a method of inhibiting the biosynthesis of cholesterol employing such pharmaceutical compositions are also disclosed.

REFERENCES:
patent: 3983140 (1976-09-01), Endo et al.
patent: 4049495 (1977-09-01), Endo et al.
patent: 4137322 (1979-01-01), Endo et al.
patent: 4198425 (1980-04-01), Mistui et al.
patent: 4255444 (1981-03-01), Oka et al.
patent: 4262013 (1981-04-01), Mistui et al.
patent: 4375475 (1983-03-01), Willard et al.
patent: 4613610 (1986-09-01), Wareing
patent: 4751229 (1988-06-01), Heifetz et al.
patent: 4767775 (1988-08-01), Jelich et al.
New Engl. J. Med., Brown et al, 305, No. 9, 515-517 (1981).
JAMA, 251, No. 3, 351-374 (1984).
Proc. Soc. Exper. Biol. Med., 102:270 (1959).
Arch. of Biochem. and Biophys., 146, 422-427 (1971).
J. Chem. Soc. Perkin I, 1165 (1976).

Affiliated with

Also associated with

Rating

Trans-6-(2-(n-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl- does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Trans-6-(2-(n-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl- , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Trans-6-(2-(n-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl- will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1895532