Preparation of C-13 hydroxyl-bearing taxanes using nocardioides

Details Preparation of C-13 hydroxyl-bearing taxanes using nocardioides Preparation of C-13 hydroxyl-bearing taxanes using nocardioides

1993-06-15

1996-05-14

Naff, David M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435117, 4352521, 4352532, 435872, 435123, 549510, 549511, C12P 1702, C12N 914, C07D30514

Patent

active

055166768

ABSTRACT:
Compounds useful as intermediates in the preparation of taxanes such as taxol are prepared by contacting one or more C-13 acyloxy-bearing taxanes with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. In a preferred embodiment the microorganism is Nocardioides albus ATCC55424, Nocardioides albus ATCC55425 or Nocardioides luteus ATCC55426 or the hydrolase enzyme is isolated from the microorganisms.

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