Synthesis of D-myoinositol-1-phosphate

Details Synthesis of D-myoinositol-1-phosphate Synthesis of D-myoinositol-1-phosphate

1990-08-31

1992-02-25

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

558194, C07F 9117

Patent

active

050915495

ABSTRACT:
A method of synthesizing D-myoinositol-1-phosphate from 1,2-(R.sup.1)-3-R.sup.2 -myoinositol compounds of the formula ##STR1## wherein R.sup.1 is a bridging type protective group bonded to two oxygen atoms at the 1- and 2-position, and R.sup.2 is a protective group coupled to the oxygen atom at the 3-position. D-Myoinositol-1-phosphate is useful as an intermediate for the production of inositol-1,4,5-triphosphate.

REFERENCES:
patent: 4873355 (1989-10-01), Hobbs et al.
M. J. Berridge et al., "Nature", vol. 306, Nov. 3, 1983, pp. 67-69.
M. J. Berridge et al., "Nature", vol. 312, Nov. 22, 1984, pp. 315-321.
S. Ozaki et al., "Tetahedron Lett.", vol. 27, No. 27, pp. 3157-3160 (1986).
D. A. Billington et al., "J. Chem. Soc., Chem. Commun", 1987, 314.
D. Mercier, "Tetrahedron", vol. 25, 1989, pp. 5681-5687.

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