Topical antinflammatory compositions with minimal systemic absor

Details Topical antinflammatory compositions with minimal systemic absor Topical antinflammatory compositions with minimal systemic absor

1989-08-31

1992-02-25

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ortho-hydroxybenzoic acid or derivative doai

514347, 514647, 514772, 514862, 514863, 514864, 514865, 514969, 514975, 548469, 548509, 548510, 424DIG13, A61K 3158

Patent

active

050913794

ABSTRACT:
Topical polyethylene glycol based formulations for the delivery of 2-substituted-1-naphthols and indoles and particularly, 2-phenylmethyl-1-naphthol are provided. Said topical formulations exert excellent localized antiinflammatory activity while demonstrating low levels of skin penetration in vitro and in vivo thereby reducing unwanted side effects and reducing systemic toxicity associated with the active drug compounds.

REFERENCES:
patent: 4473565 (1984-09-01), Rouee et al.
patent: 4575515 (1986-03-01), Sandborn
patent: 4833164 (1989-05-01), Batt
patent: 4895727 (1990-01-01), Allen
Batt et al., U.S. Patent Application No. 07/293,522.

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