Phosphorus-containing HMG-CoA reductase inhibitors, new intermed

Details Phosphorus-containing HMG-CoA reductase inhibitors, new intermed Phosphorus-containing HMG-CoA reductase inhibitors, new intermed

1988-04-18

1992-02-25

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 81, 556405, 558179, 558182, 548413, 548414, 548119, 549 6, 549218, 549222, C07F 96503, C07F 96506, C07F 9572, C07F 96553

Patent

active

050913786

ABSTRACT:
Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesteroleumic agents are provided which have the structure ##STR1## wherein R is OH, or salts thereof or lower alkoxy; R.sup.x is H or alkyl;

REFERENCES:
patent: 3983140 (1976-09-01), Endo et al.
patent: 4049495 (1977-09-01), Endo et al.
patent: 4137322 (1979-01-01), Endo et al.
patent: 4375475 (1983-03-01), Willard et al.
patent: 4613610 (1986-09-01), Wareing
patent: 4647576 (1987-03-01), Hoefle et al.
Nakamara et al., Biochem 24, 1364 (1985).
Singer et al., Proc. Soc. Exper. Biol. Med., 102, 370 (1982) "New Inhibitor of in vitro Conversion of Acetate and Mevalonate to Cholesterol".
Hulcher, Arch. Biochem. Biophys., 146, 422 (1971), "Inhibition of Hepatic Cholesterol Biosynthesis by 3,5-Dihydroxy-3,4,4-Trimethylvaleric Acid and Its Site of Action".
Brown et al., J. Chem. Soc. Perkin I., 1165 (1976), "Crystal and Molecular Structure of Compactin, A New Antifungal Metabolite from Penicillium breviocompactum".
Baader Tetrahedron Letters, vol. 29, No. 8, 929-930, 1988.
Anderson, Chem Abs 105, 78767m.

Affiliated with

Also associated with

Rating

Phosphorus-containing HMG-CoA reductase inhibitors, new intermed does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phosphorus-containing HMG-CoA reductase inhibitors, new intermed, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phosphorus-containing HMG-CoA reductase inhibitors, new intermed will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1893053