Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1990-06-04
1992-02-25
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530326, 530327, 530321, 530317, 514 13, 514 14, 930DIG553, C07K 764, A61K 3702
Patent
active
050913662
ABSTRACT:
Analogs of the 17-membered ring portion of ANF wherein the cysteine moiety is replaced with dipeptidyl moieties, specifically, Phe-Pro, NMP-Pro, Pro-Pro, Val-Pro, Lys-Pro, Ile-Pro, Arg-Pro, HAr-Pro, Dly-Pro, Arg-Pro, Lys-BAr, Arg-Pro, CyA-CyA, Cys-Cys, or with .alpha.-aminoheptanoic acid result in analogs of ANF having increased potencies and metabolic stability.
REFERENCES:
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Dayoff, M., Atlas of Protein Sequence and Structure, vol. 5, 89-99, 1972.
Kohzuhi, M. et al., Chem. Abs., 110:152096p, 1989.
Raine, A. et al., New England Journal of Medicine, 315(9):533-537, 1986.
Edwards, B. et al., Cardiovascular Drugs and Therapy, 1:89-100, 1987.
Tsunoda et al., Chem. Abs., 108:92513u, 1988.
Kiso et al., Peptides: Struc. and Function, Proc. of the 9th Am. Peptide Symp., Ed. Deber, Kapple, 1985.
PCT/WO8 7/02674, published 7.5.87, Lewieki, pp. 97-123.
Kiso, Y. et al., Peptides: Struc. and Func., Proceeding of 9th Am. Pept. Symp., Pierce Chem. Co., 949-952, 1985.
Brady Stephen F.
Ciccarone Terrence M.
Nutt Ruth F.
Veber Daniel F.
Grassler Frank P.
Merck & Co. , Inc.
Perkins Susan M.
Perrella Donald J.
Pfeiffer Hesna J.
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