Cyclic peptides as promoters of absorption on administration ont

Details Cyclic peptides as promoters of absorption on administration ont Cyclic peptides as promoters of absorption on administration ont

1988-08-05

1992-02-25

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 13, C07K 512, A61K 3702

Patent

active

050913654

ABSTRACT:
The invention relates to the use of aids of the general formula ##STR1## in which B denotes a basic amino acid, A/B denotes an acidic or basic amino acid, X denotes a neutral and hydrophilic amino acid, L denotes a lipophilic neutral amino acid, and R denotes hydrogen or an acyl radical, or the physiologically tolerated salts thereof, for promoting the absorption of peptides and proteins on administration onto the mocosa, as well as to pharmaceutical compositions which contain a pharmacologically effective amount of one or more peptides or proteins as well as an aid of the abovementioned formula.

REFERENCES:
patent: 4434159 (1984-02-01), Sekine et al.
patent: 4537772 (1985-08-01), Alexander et al.
patent: 4613500 (1986-09-01), Suzuki et al.
patent: 4789667 (1988-12-01), Makino et al.
patent: 4900730 (1990-02-01), Miyauchi
J. Sandow, W. Petri, "Intranasal Administration of Peptides Biological Activity and Therapeutic Efficacy", Transnasal Systemic Medications, pp. 183-199 (1985).
Chemical Abstracts, Pharmaceuticals for Rectal Application, vol. 97, p. 400, 97:98358y.

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