Agent for the therapy of factor VIII-resistant hemophilia A, and

Details Agent for the therapy of factor VIII-resistant hemophilia A, and Agent for the therapy of factor VIII-resistant hemophilia A, and

1988-08-10

1992-02-25

Rosen, Sam

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424 943, 424529, 514 8, 514 21, 530381, 530383, 530830, A61K 3702

Patent

active

050913638

ABSTRACT:
An agent for the therapy of hemophilia A which is resistant to treatment with factor VIII is described, and is obtainable by maintaining a mixture of factor VIII, antithrombin III, a phospholipid and calcium ions in an aqueous solution at a temperature of from 1.degree. to 45.degree. C. for at least one minute, adding factor IX, and maintaining the solution at a temperature offrom 1.degree. to 45.degree. C. until addition of a sample of this solution to an inhibitor plasma results in a partial thromboplastin time (PTT) of 15 to 30 seconds, where appropriate adding a polyol and, where appropriate, an amino acid, and, where appropriate, drying the solution.

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