Process for producing 2-fluoroisobutyric acid ester

Details Process for producing 2-fluoroisobutyric acid ester Process for producing 2-fluoroisobutyric acid ester

1992-03-23

1992-12-29

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560226, 562602, 562603, 562605, C07C 5315, C07C 5321, C07C 6963, C07B 3900

Patent

active

051753456

ABSTRACT:
A 2-fluoroisobutyric acid ester can be obtained at a high yield in one pot by reacting a 2-hydroxyisobutyric acid ester with fluorosulfuric acid in the absence or presence of a hydrogen fluoride source, or by reacting a 2-hydroxyisobutyric acid ester with chlorosulfuric acid in the presence of a hydrogen fluoride source.

REFERENCES:
patent: 5049676 (1991-09-01), Metivier et al.
Genssler et al., "Fluorination of Methyl Isobutyrate with Perchoryl Fluoride", J. Org. Chem. NOTES, vol. 33, No. 11, Nov. 1968, 4279-4281.
Purrington et al., "Preparation of .alpha.-Fluoro Carboxylic Acids and Derivatives", J. Org. Chem., vol. 55, 1990, 3423-3424.

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