Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1988-07-01
1992-12-29
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 11, 536 187, 536 22, 536 23, 536 28, 536 29, C07H 19073, C07H 2104, C07H 1518
Patent
active
051752735
ABSTRACT:
Pyridinone or pyrimidinone nucleoside bases containing fused aromatic polycyclic rings are provided. These polycyclic nucleosides are incorporated into oligonucleotides and hybridized to complementary nucleic acid. Fluorescence spectroscopy and thermal denaturation profiles provided evidence that the polycyclic base is intercalated into the resulting duplex. The fused polycyclic ring systems optionally are substituted with reactive species which inactivate complementary nucleic acids. The oligonucleotides of this invention are useful as improved probes, diagnostic reagents, or for cleaving or derivatizing predetermined domains within nucleic acids.
REFERENCES:
patent: 3893998 (1975-07-01), Secrist et al.
patent: 4277466 (1981-07-01), Trouet
patent: 4373071 (1983-02-01), Itakura
patent: 4547569 (1985-10-01), Letsinger et al.
patent: 4797480 (1989-01-01), Sorbi et al.
patent: 4835263 (1989-05-01), Nguyen et al.
Stryer, Biochemistry, 3rd Ed., W H Freeman & Co, N.Y., pp. 654-655.
Alberts et al., Molecular Biology of the Cell, pp. 95-96, 98-99 2nd ed., Garland Publishing, Inc., New York & London.
Watson et al., Molecular Biology of the Gene, 4th ed., Benjamin/Cummings Publishing Co., Inc., Menlo Park, Calif., pp. 254-255.
Morrison & Boyd, Organic Chemistry, 4th ed., Allyn and Bacon, Inc., Mass., pp. 1249-1251, 1284-1285.
Aldrich Fine Chemicals, Aldrich Chemical Co., Inc. (1986) p. 1411.
The Merck Index, 10th ed., Martha Windholz, editor, [pp. ONR-84, ONR-15, 1021,] Merck & Co., Inc., Rahway, N.J. (1983), 158, 150, 159.
Bischofberger Norbert W.
Matteucci Mark D.
Brown Johnnie R.
Genentech Inc.
Hensley Max D.
Kunz Gary L.
Winter Daryl B.
LandOfFree
Nucleic acid intercalating agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acid intercalating agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid intercalating agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1888312