Preparation of phenoxy-substituted esters and intermediates ther

Details Preparation of phenoxy-substituted esters and intermediates ther Preparation of phenoxy-substituted esters and intermediates ther

1987-12-07

1989-09-26

Gray, Bruce

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560231, 560255, 560263, 560264, 560266, C07C 6702

Patent

active

048702056

ABSTRACT:
Compounds of the formula I ##STR1## where A is C.sub.1 -C.sub.4 -alkyl, phenyl or C.sub.7 -C.sub.12 -aralkyl and l is 0 or 1, R.sup.2 is C.sub.1 -C.sub.4 -alkyl, n is 0, 1, 2 or 3, m is 1, 2 or 3 and Y is hydrogen, fluorine, chlorine, bromine, C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.3 -alkoxy, trifluoromethyl, phenyl or phenoxy, and, where m is greater than 1, the individual atoms or groups Y are identical or different, are prepared by a process in which, in a first stage, a diester of the formula II ##STR2## is hydrolyzed with one equivalent of an aqueous alkali metal hydroxide to give the alcohol of the formula IIIa ##STR3## in a second stage this alcohol is converted with a halo-generating agent or a sulfonyl chloride or bromide into a compound of the formula IIIb ##STR4## where X is a necleophilically displaceable leaving group, such as chlorine, bromine, mesyl or tosyl, and then, in a third stage, the compound IIIb is reacted with a phenolate of the formula IV ##STR5## where Y and m have the abovementioned meanings, in the presence of an aprotic solvent to give compound I. Furthermore, diesters of the formula II and a process for their preparation are provided, the said diesters being prepared by reacting a lactone of the formula V ##STR6## with a Grignard compound VI

REFERENCES:
patent: 4380546 (1983-04-01), Sauter et al.
March, Advanced Organic Chemistry, 2nd Edition, pp. 439-440 (1977).

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