Process for the preparation of 5-hydroxymethylthiazole

Details Process for the preparation of 5-hydroxymethylthiazole Process for the preparation of 5-hydroxymethylthiazole

1996-12-09

1998-07-14

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548200, C07D27724

Patent

active

057806381

ABSTRACT:
5-Hydroxymethylthiazole is prepared in an improved manner by reducing 5-formylthiazole using a borane compound. Particularly advantageous in this case is the use of 5-formylthiazole which has been obtained by reaction of a 2-halomalonaldehyde compound with thioformamide in the presence of less than 5% by weight of water (based on the reaction mixture).

REFERENCES:
Kerdesky,Synthetic Communication, 25(17), 2639, 1995.
Lancaster Catalog pp. 190-191, 1995.
Potts Comprehensive Heterocyclic Chemistry, vol. 6, p. 295, 1984.
von H. Erlenmeyer, et al., 245. Zur Kenntnis des
van S. Fallab, 27, Uber Thiazolyl-(5)-carbinol, Helv. Chim. Acts., 35, 215, (1952).

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