Process for thiopyrans

Details Process for thiopyrans Process for thiopyrans

1996-01-05

1998-07-14

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40904

Patent

active

057806365

ABSTRACT:
The invention relates to a process for the preparation of intermediates useful in the preparation of (1R,2R)-2-(3-pyridyl)-N-alkyltetrahydro-2H-thiopyran-2-carbothioamide 1-oxides, which possess useful pharmaceutical properties, for example antihypertensive properties, and to intermediates and pharmaceutical products prepared using said process.

REFERENCES:
patent: 4568682 (1986-02-01), Aloup et al.
patent: 5120852 (1992-06-01), Aloup et al.
J. Med. Chem., vol. 35, No. 20, 1992, 3613-3624, Brown wt. al., Synthesis and Biological Activity of trans-(.+-.)-N-Methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-Oxide (RP 49356) and Analogues: A New Class of Potassium Channel Opener.

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