Method and compositions for inhibition of adaptor protein/tyrosi

Details Method and compositions for inhibition of adaptor protein/tyrosi Method and compositions for inhibition of adaptor protein/tyrosi

1996-06-05

1998-07-14

Davis, Zinna Norhington

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548455, A61K 3140, C07D20904

Patent

active

057804966

ABSTRACT:
The present invention relates to methods and compositions for the inhibition of adaptor protein/protein tyrosine kinase protein interactions, especially wherein those interactions involving a protein tyrosine kinase capable of completing with a member of the SH2- and/or SH3-containing family of adaptor proteins are associated with a cell proliferative disorder. Specifically, the present invention relates to particular compounds, especially quinazoline derivative compounds, and methods utilizing such compounds.

REFERENCES:
patent: 3917820 (1975-11-01), Brewer et al.
Arai, K., S. Shimizu, and Y. Yamamoto. 1981. Metabolic products of Aspergillus Terreus. VI Metabolites of the Strain IFO 8835 (3). The isolation and chemical structures of colorless metabolites. Chem. Pharm. Bull. 29:1005-1012.
Arai, K. et al. 1981. Metabolic products of aspergillus terreus. IV. Metabolites of the strain IFO 8835. (2) The isolation and chemical structure of indoly benzoquinone pigments. Chem. Pharm. Bull. 29:961-969.
Arai, K., S. Shimizu, Y. Taguchi, and Y. Yamamoto. 1981. Metabolic products of aspergillus terreus. V. Demethylation of asterriquinones. Chem. Pharm. Bull. 29:991-999.
Arai, K., and Y. Yamamoto. 1990. Metabolic products of aspergillus terreus. X. Biosynthesis of asterriguinones. Chem. Pharm. Bull. 38:2929-2932.
Brewer, D., W. A. Jerram, and A. Taylor. 1968. The production of cochliodinol and a related metabolite by chaetomium species. Canadian Journal of Microbiology 14:861-866.
Horcher, U., E. Schwenner, and B. Franck. 1986. Totalsynthese des cochliodinols. Liebigs Ann. Chem. 1765-1771.
Jerram, W. A., A. G. Mclnnes, W. S. G. Maass, D.G. Smith, A. Taylor, and J. A. Walter. 1974. The chemistry of cochliodinol, a metabolite of chaetomium spp. Can. J. Chem. 53:727-737.
Kaji, A., N. Iwata, S. Wakusawa, and K-i. Miyamoto. Aug. 1994. Four New Metabolites of Aspergillus Terreus.Chem. Pharm. Bull. 42:1682-1684.
Kaji, A. et al. Oct. 1995. Partial decetylation of asterriquinone diacetate by aqueous sodium bicarbonate in pyridine. Chem. Pharm. Bull. 43:1818-1820.
Meiler, D., and A Taylor. 1970 The effect of cochlidinol, a metabolite of chaetomium cochliodes, on the respiration of microspores of fusarium oxysporum. Canadian Journal of Microbiology 17:83-86.
Mocek, U. et al. 1995. Isolation and structure elucidation of five new asterriquinones from Aspergillus, Humicola and Botryotricum species. Hauser Natural Products Chemistry Symposium--24 May 1995.
O'Leary, A., and J.R. Hanson. 1982. Hinnuliquione, A Bis-indoly-2,5-dihyroxbenzoquinone pigment from nodulisporium hinnuleum. Tetrahedron Letters 23:1855-1856.
Ono, K., H. Nakane, S. Shimizu, and S. Koshimura. 1991. Inhibition of HIV-reverse transcriptase activity by asterriquinone and its analogues. Biochemical and Biophysical Research Communications 174:56-62.
Sekita, S. 1983. Isocochliodinol and neocochilodinol, Bis(3-indolyl)-benzoquinones from chaetomium spp. Chem. Pharm. Bull. 31:2998-3001.
Shimizu, S. and S Koshimura. 1990. Interaction of asterriquinone with deoxyribonucleic acid in vitro. Chem. Pharm Bull. 38:2617-2619.
Shimizu, S., Y. Yamamoto and S. Koshimura. 1982. Antitumor activity of asterriquinones from Aspergillus Fungi. IV. An attempt to modify the structure of asterriquinones to increase the activity. Chem. Pharm. Bull. 30:1896-1899.
Shimuzu, S., Y. Yamamoto, J-i. Inagaki, and S. Koshimura. 1982. Antitumor effect and structure-activity relationship of asterriquinone analogs. Gann. 73:642-648.
Yamamoto, Y., N. Kiriyama, S. Shimizu and S. Koshimura. 1976. Antitumor Activity of Asterriquinone, A Metabolic Product from Aspergillus Terreus. Gann 67:623-624.
Yamamoto, Y., K-i. Nishimura, and N. Kiryama. 1976. Studies on the Metabolic products of aspergillus terreus. I. metabolites of the strain IFO 6123. Chem. Pharm. Bull. 24:1853-1859.

Affiliated with

Also associated with

Rating

Method and compositions for inhibition of adaptor protein/tyrosi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and compositions for inhibition of adaptor protein/tyrosi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and compositions for inhibition of adaptor protein/tyrosi will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1882175