Process for preparing 3-substituted-6-substituted-7-oxo-1-azabic

Details Process for preparing 3-substituted-6-substituted-7-oxo-1-azabic Process for preparing 3-substituted-6-substituted-7-oxo-1-azabic

1985-07-29

1988-05-17

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540310, C07D48704, A61K 3140

Patent

active

047451882

ABSTRACT:
Disclosed is a process for preparing 3- and 6-substituted-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acids: ##STR1## wherein: X is a leaving group such as chloro, bromo, tosyl, mesyl or the like; and R.sup.6, R.sup.7 and R.sup.8 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl. Such compounds (I), as well as their pharmaceutically acceptable salt, ester and amide derivatives, are useful as antibiotics.

REFERENCES:
patent: 3992377 (1976-11-01), Chauvette
patent: 4256739 (1981-03-01), Woodward et al.
Scartazzini et al., Helvetica Chemica Acta, 58(8), 1975, pp. 2437-2450.

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