Methods for stimulating neurite growth with piperidine compounds

Details Methods for stimulating neurite growth with piperidine compounds Methods for stimulating neurite growth with piperidine compounds

1996-11-13

1998-07-14

Jarvis, William R. A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514317, 514318, 5142372, 514314, 514 12, A61K 31445, A61K 31535, A61K 3147, A61K 3818

Patent

active

057804842

ABSTRACT:
The present invention relates to methods for stimulating the growth of neurites in nerve cells. The methods comprise treating nerve cells with piperidine compounds alone or in combination with a neurotrophic factor, such as nerve growth factor. The methods of this invention can be used to promote repair of neuronal damage caused by disease or physical trauma.

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B.G. Gold et al., "The immunosuppressant FK506 increases the Rate of Axonal Regeneration in Rat Sciatic Nerve," J. Neuroscience., 15(11), pp. 7509-7516 (Nov., 1995).
W.E. Lyons et al., "Immunosupressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia," Proc. Natl. Acad. Sci. USA, 91, pp. 3191-3195 (Apr., 1994).
John Sharkey et al., "Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia." Nature, 371, pp. 336-339 (Sep. 22, 1994).
W.E. Lyons et al., "Neuronal regeneration enhances the expression of the immunophilin FKBP-12," J. Neuroscience., 15, pp. 2985-2994 (Apr., 1995).

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