Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-05-06
1998-07-14
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540545, 514410, A61K 3140, C07D49822
Patent
active
057804613
ABSTRACT:
This invention provides novel bis-indolemaleimide macrocycle derivatives of the formula: ##STR1## The invention further provides the preparation, pharmaceutical formulations and the methods of use for inhibiting Protein Kinase C in mammals. The compounds of the present invention can be used to treat cancer and inhibiting tumor growth in mammals.
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Heath, Jr. William F.
Jirousek Michael R.
McDonald, III John H.
Rito Christopher J.
Boone David E.
Caltrider Steven P.
Eli Lilly and Company
Shah Mukund J.
Sripada Pavanaram K.
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