Treatment of pulmonary disease with protease inhibitors

Details Treatment of pulmonary disease with protease inhibitors Treatment of pulmonary disease with protease inhibitors

1996-10-11

1998-07-14

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 514 12, 514921, 530395, 530397, 424 942, 424 9464, A61K 3800, A61K 3846

Patent

active

057804400

ABSTRACT:
The invention relates to methods and compositions for the prevention or treatment of patients suffering from respiratory distress syndrome and/or sepsis syndrome by administering directly into the lungs small or nicrocrystalline particles or droplets of at least one protease inhibitor alone or with an oxygen metabolite scavenger. The method can also include the treatment in combination with the monitoring of the urine desmosine level of the patients and the use of DNase.

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Gillissen et al, J. Appl. Physiol., vol. 75, No. 2, pp. 825-832, 1993.
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Ohlsson et al, Acta Paediatrica, vol. 81, No. 10, pp. 757-759, 1992.
O'Donovan et al, European Journal of Gastroenterology &Hepatology, vol. 7, No. 9, pp. 842-852, 1995.

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