Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1984-12-28
1988-05-17
Warren, Charles F.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435 6, 435320, 435253, 536 27, 935 9, 935 27, 935 72, 935 78, C12N 1500, C12N 120, C12Q 168, C07H 2100
Patent
active
047450606
ABSTRACT:
Recombinant DNA transfer vectors containing DNA inserts which are complementary to either the human LDL receptor gene, or its mRNA transcript, are disclosed. Also disclosed are methods which utilize these genetic probes for diagnosing Familial Hypercholesterolemia (FH) in a suspected individual. A case study of one such individual, FH 274, is disclosed wherein the genetic deletion mutation is detailed with great precision through the practice of this invention.
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Brown Michael S.
Goldstein Joseph L.
Russell David W.
Board of Regents , The University of Texas System
Jay Jeremy M.
Warren Charles F.
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