Human voltage-dependent anion channel

Details Human voltage-dependent anion channel Human voltage-dependent anion channel

1996-10-04

1998-07-14

Scheiner, Toni R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 723, 530350, 536 231, 536 2431, G01N 33574, C07H 2104

Patent

active

057802351

ABSTRACT:
The present invention provides a polynucleotide which identifies and encodes a novel human voltage-dependent anion channel HACH and HACH itself. The invention provides for genetically engineered expression vectors, host cells containing the vector and a method for producing HACH. The invention also provides a method for identifying pharmaceutical compositions inhibiting the expression and activity of HACH and for the use of such compositions for the treatment of cancer and proliferative diseases. The invention also provides diagnostic assays which utilize the polynucleotide to hybridize with the transcripts encoding HACH or anti-HACH antibodies which specifically bind to HACH in normal or diseased tissues.

REFERENCES:
Blachly-Dyson et al., "Cloning and Functional Expression in Yeast of Two Human Isoforms of the Outer Mitochondrial Membrane Channel, the Voltage-dependent Anion Channel" J. Biol. Chem. 268(3):1835-41 (1993) (Accesssion GI 340201).
Ha et al., "A Mitochondrial Porin cDNA A Predicts the Existence of Multiple Human Porins" J. Biol. Chem. 268(16):12143-9 (1993).
Nakashima et al., "Hexokinase receptor complex in hepatoma mitochondria: evidence from N,N'-dicyclohexylcarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC" Biochemistry 25:1015-21 (1986).
Sampson et al., "A novel mouse mitochondrial voltage-dependent anion channel gene localizes to chromosome 8" Genomics 36(1):192-196 (1996) (Accession GI 1463028).
Blachly-Dyson et al., "Selectivity changes in site-directed mutants of the VDAC ion channel: structural implications" Science 247:1233-36 (1990).
Hillier, et al., Genbank Version 97 data base, accession No. H87603, 21 Nov. 1995.
Hillier et al., Genbank Version 97 data base, accession No. H45094, 31 Jul. 1995.
Hillier et al., Genbank Version 97 data base, accession No. AA031869, 21 Aug. 1996.
Hillier et al., Genbank Version 97 data base, accession No. N24324, 28 Dec. 1995.
Liew, C.C., Genbank Version 97 data base, accession No. N86098, 01 Apr. 1996.

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