Novel carbacyclinamides, their preparation and use as medicinal

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514613, 544176, 564189, C07C17700, A61K 31557

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active

045528756

ABSTRACT:
Carbacyclinamides of Formula I ##STR1## wherein R.sub.1 is NHR.sub.4, wherein R.sub.4 is H, --(CH.sub.2).sub.n --R.sub.8 or straight-chained or branched aliphatic groups of 1-10 carbon atoms, cycloalkyl of 3-10 carbon atoms, aryl, or lower mono- or polyhydroxyalkyl of 2-8 carbon atoms, or R.sub.1 is NR.sub.4 R.sub.5 wherein R.sub.4 and R.sub.5 each are straight-chained or branched, lower, mono- or polyhydroxyalkyl of 2-8 carbon atoms, or R.sub.4 and R.sub.5 together with the adjoining N-atom form a 5- or 6-membered heterocycle which can optionally contain additional hetero atoms and can be substituted; or R.sub.1 is NR.sub.4 R.sub.5 wherein R.sub.4 is an aliphatic group of 1-10 carbon atoms, cycloalkyl of 3-10 carbon atoms, and R.sub.5 is straight-chained or branched aliphatic group of 1-10 carbon atoms, cycloalkyl of 3-10 carbon atoms, aryl, or lower, mono- or polyhydroxyalkyl of 2-8 carbon atoms;

REFERENCES:
patent: 4238414 (1980-12-01), Morton, Jr.
patent: 4306075 (1981-12-01), Aristoff
patent: 4306076 (1981-12-01), Nelson
patent: 4307112 (1981-12-01), Gandolfi et al.
patent: 4322435 (1982-03-01), Kojima et al.
patent: 4338457 (1982-07-01), Aristoff
patent: 4346041 (1982-08-01), Aristoff
patent: 4423067 (1983-12-01), Skuballa
European Search Report No. EP 83 73 0065, dated 07/09/83.

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