Use of diamino alcohols as analgesic agents

Details Use of diamino alcohols as analgesic agents Use of diamino alcohols as analgesic agents

1984-07-05

1985-11-12

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 17, 514 18, 514 19, 2601125R, A61K 3700, C07C10352

Patent

active

045528667

ABSTRACT:
An enkephalin-degrading aminopeptidase enzyme is inhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salt thereof, wherein R.sub.1 and R.sub.2 are each independently hydrogen, alkyl, carboxyalkyl, halo substituted alkyl, hydroxyalkyl, aminoalkyl, mercaptoalkyl, alkylthioalkyl, (cycloalkyl)alkyl, (heteroaryl)alkyl, arylalkyl, carbamoylalkyl, guanidinylalkyl, or heteroaryl;

REFERENCES:
H. Umezawa et al., J. Antibiotics, vol. 29, p. 97, (1976).
H. Suda et al., J. Antibiotics, vol. 29, p. 100, (1976).
T. Aoyagi et al., J. Antibiotics, vol. 31, p. 636, (1978).
H. Tobe et al., Agric. Biological Chemistry, vol. 43, p. 591, (1979).
Inhibition of Brain Aminopeptidase by Bestatin and Analogs, G. W. Wagner & J. E. Dixon, J. Neurochem. vol. 37, p. 709, (1980).

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