Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Patent
1996-02-08
1998-07-14
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
424 59, 514887, 426 72, A61K 740
Patent
active
057800421
DESCRIPTION:
BRIEF SUMMARY
This application is a continuation of PCT/DE94/00078 published Jan. 29, 1994.
The present invention relates to light protection formulations in particular cosmetic and dermatological light protection agents.
The damaging effect of the ultraviolet component of solar radiation on the skin is generally known. While rays having a wavelength of less than 290 nm (the so-called UVC range) are absorbed by the ozone layer in the earth's atmosphere, rays in the range between 290 nm and 320 nm, the so-called UVB range, cause erythema, simple sunburn or burns of greater or lesser severity.
The narrower range around 308 nm is stated as having the maximum erythema activity of sunlight.
Numerous compounds are known for protection against UVB radiation, these being derivatives of 3-benzylidenecamphor, of 4-aminobenzoic acid, of cinnamic acid, of salicylic acid, of benzophenone and also of 2-phenylbenzimidazole.
It is also important to have filter substances available for the range between about 320 nm and about 400 nm, the so-called UVA range, since its rays can also cause damage. Thus, it has been proved that UVA radiation causes damage to the elastic and collagenic fibres of the connective tissue, which ages the skin prematurely, and that it is to be regarded as the cause of numerous phototoxic and photoallergic reactions. The harmful influence of UVB radiation can be intensified by UVA radiation.
Certain derivatives of dibenzoylmethane are therefore used for protection against rays in the UVA range, the photostability of which derivatives (Int. J. Cosm. Science 10, 53 (1988)) is not adequate.
However, UV radiation can also lead to photochemical reactions, the photochemical reaction products intervening in skin metabolism.
Such photochemical reaction products are chiefly free-radical compounds, for example hydroxy radicals. Undefined free-radical photoproducts which are formed in the skin itself can also display uncontrolled secondary reactions because of their high reactivity. Singlet oxygen, an excited state of the oxygen molecule without free radicals, however, can also occur under UV irradiation, as can short-lived epoxides and many other compounds. Singlet oxygen, for example, is distinguished by an increased reactivity compared with the triplet oxygen usually present (free-radical ground state). Nevertheless, excited, reactive (free-radical) triplet states of the oxygen molecule also exist.
In order to prevent these reactions, antioxidants and/or agents which trap free radicals can additionally be incorporated into cosmetic or dermatological formulations.
The compounds, some of which are mentioned above, which are employed as light protection agents for cosmetic and dermatological light protection formulations are distinguished by a good light protection action. However, they have the disadvantage that it is sometimes difficult for them to be incorporated into such formulations in a satisfactory manner. Furthermore, these compounds are pure UV-absorbing agents and are unsuitable as agents which trap free radicals.
It has already been proposed to employ vitamin E, a substance having a known antioxidative action, in light protection formulations but, here also, the action achieved remains far below that hoped for.
However, it was surprising and not to be foreseen by the expert that active compound combinations comprising a combination of at least one substance chosen from the group consisting of 2,4-O-furfurylidenesorbitol and alkyl ethers thereof and at least one substance chosen from the group consisting of cosmetically or pharmaceutically acceptable antioxidants, and cosmetic and dermatological light protection formulations having an active content of a combination of at least one substance chosen from the group consisting of 2,4-O-furfurylidenesorbitol and alkyl ethers thereof and at least one substance chosen from the group consisting of cosmetically or pharmaceutically acceptable antioxidants, but in particular active compound combinations comprising a combination of at least one substance chosen from the grou
REFERENCES:
patent: 5135946 (1992-08-01), Bertelli
Gers-Barlag Heinrich
Muller Anja
Sauermann Gerhard
Uhlmann Beate
Beiersdorf AG
Faullener D.
Page Thurman K.
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