Heterocyclic substituted indolinones

Details Heterocyclic substituted indolinones Heterocyclic substituted indolinones

1987-09-10

1989-09-26

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544 8, 544 68, 544230, 544182, 544238, 548265, 548364, 548410, 548486, A61K 3150, C07D40310, C07D41310, C07D41710

Patent

active

048700770

ABSTRACT:
Heterocyclic substituted indolinones of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom or an alkyl or hydroxyalkyl radical, R.sub.2 is a carboxyl group or an alkoxy-carbonyl, hydroxyalkyl or alkylcarbonyloxyalkyl radical or R.sub.1 and R.sub.2, together with the carbon atom to which they are attached, form a lactone having 4, 5 or 6 ring atoms, A-B is --CH.sub.2 --CH(R.sub.3)--, --CH.dbd.CR.sub.3 --, --CH.sub.2 --NH--, --NH--CH.sub.2 --, --CH.sub.2 --O--, --O--CH.sub.2 --, --CH.sub.2 --S-- or --S--CH.sub.2 -- radical, R.sub.3 being a hydrogen atom or an alkyl or hydroxyalkyl radical, or A is a valency bond and B is a methylene radical ##STR2## or an imino group ##STR3## R.sub.4, R.sub.5, and R.sub.6 independently being hydrogen atoms or alkyl radicals wherein the alkyl groups independently contain 1 to 6 carbon atoms; as well as the tautomers thereof and the physiologically acceptable salt thereof and the physiologically acceptable salts thereof with inorganic and organic acids, are disclosed, such as, for instance, the compound 5-(2,3,4,5-tetrahydro-3-oxopyridazin-6-yl)-3-ethoxycarbonyl-3-methyl-1H-in dol n-2-one. The compounds of the invention are useful in the treatment of heart and circulatory diseases, for example, by producing a positive inotropic action in a patient to whom the compounds are administered.

REFERENCES:
patent: 4617302 (1986-10-01), Robertson
"Nomenclature of Organic Chemistry" (IUPAC, 1969), pp. 202-205.
NAKAO Chemical Abstracts; vol. 91, 5240p (1979).
Search Report and Abstract for EP259,871 (1987).

Affiliated with

Also associated with

Rating

Heterocyclic substituted indolinones does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heterocyclic substituted indolinones, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocyclic substituted indolinones will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-187886