Process and intermediates for the synthesis of Vitamin D.sub.3 m

Details Process and intermediates for the synthesis of Vitamin D.sub.3 m Process and intermediates for the synthesis of Vitamin D.sub.3 m

1980-10-22

1982-11-23

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603972, 2603975, C07J 900

Patent

active

043604706

ABSTRACT:
The present disclosure is directed to a process for the synthesis of chenodeoxychloic acid, 25-hydroxycholesterol and 1.alpha.,25-dihydroxycholesterol from 17-keto steroids. A cholic acid side chain is stereospecifically introduced by reaction of the appropriate 17-keto steroid with ethyltriphenylphosphonium halides to produce the 17-ethylidene derivative which is allowed to react with acrylic acid esters or propiolic acid esters followed by hydrogenation.

REFERENCES:
patent: 4269777 (1981-05-01), De Luca et al.
Chem. Abstracts vol. 81 (1974) pars. 25,848T.

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