Method of using 2-formylpyridine thiosemicarbazone compounds

Details Method of using 2-formylpyridine thiosemicarbazone compounds Method of using 2-formylpyridine thiosemicarbazone compounds

1996-08-22

1998-02-24

Davis, Zinna Northington

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514375, 546292, 546305, C07D21302, A61K 3144

Patent

active

057212597

ABSTRACT:
A method of treatment of tumors is provided based upon a compound of the formula ##STR1## wherein one of R.sup.1 is NHR.sup.4 or NR.sup.4 R.sup.5 or R.sup.3 is NHR.sup.4, NR.sub.4 R.sup.5 or OH, and the other is hydrogen;

REFERENCES:
patent: 4719221 (1988-01-01), Morrison
H. L. Elford et al., "Ribonucleotide Reductase and Cell Proliferation I. Variations of Ribonucleotide Reductase Activity with Tumor Growth Rate in a Series of Rat Hepatomas," J. Biol. Chem., vol. 245, pp. 5228-5233 (1970).
R. C. DeConti et al., "Clinical and Pharmacological Studies with 5-Hydroxy-2-Formylpyridine Thiosemicarbazone," Cancer Res., vol. 32, pp. 1455-1462 (1972).
I. H. Krakoff et al., "Clinical Trial of 5-Hydroxypicolinaldehyde Thiosemicarbazone (5-HP; NSC-107392), With Special Reference to Its Iron-Chelating Properties," Cancer Chemother. Rep., vol.58, pp. 207-212 (1974).
E. C. Moore et al., "Inhibition of Deoxyribonucleotide Synthesis by Pyridine Carboxaldehyde Thiosemi-carbazones," Cancer Res., vol. 31, pp. 235-238 (1971).
K. C. Agrawal et al., "Potential Antitumor Agents. 13. 4-Methyl-5-Amino-1-Formylisoquinoline Thiosemicarbazone," J. Med. Chem., vol. 19, pp. 970-972 (1976).
K. C. Agrawal et al., "4-Methyl-5-Amino-1-Formylisoquinoline Thiosemicarbazone, a Second-Generation Series," Cancer Res., vol. 37, pp. 1692-1696 (1977).
F. A. French et al., ".alpha.-(N)-Formylheteroaromatic Thiosemicarbazones. Inhibition of Tumor-Derived Ribonucleoside Diphosphate Reductase and Correlation with In Vivo Antitumor Activity," J. Med. Chem., vol. 17, pp. 172-181 (1974).
L. Achremowicz et al., "Reactions of 3-Nitropicolines N-Oxides with Acetic Anhydride," Roczniki Chemii, vol. 46, pp. 409-419 (1972).
M. C. Liu et al., "A One-Pot Synthesis of 3-Nitro- and, 3,5-Dinitro-2-Picolines," Synth. Commun., vol. 20(19), pp. 2965-2970 (1990).
E. J. Blanz, Jr. et al., "The Carcinostatic Activity of 5-Hydroxy-2-Formylpyridine Thiosemicarbazone," Cancer Res., vol. 28, pp. 2419-2422 (1968).
K. C. Agrawal et al., "Potential Antitumor Agents. 9.2-Formyl(m-Amino)Phenylpyridine Thiosemicarbazones," J. Med. Chem., vol. 17, No. 6, pp. 631-635 (1974).
K. C. Agrawal et al., "Potential Antitumor Agents. 14. 4-Substituted 2-Formylpyridine Thiosemicarbazones," J. Med. Chem., vol. 19, No. 10, pp. 1209-1214 (1976).
S. Furukawa, "Synthesis of Pyridine Derivatives. VII. Nitration of 2,4-Lutidine," J. Pharm. Soc. Japan, vol. 76, pp. 900-902 (1956).
R. H. Dodd et al., "Hybrid Molecules: Growth Inhibition of Leishmania Donovani Promastigotes by Thiosemicarbazones of 3-Carboxy-.beta.-Carbolines," J. Med. Chem., vol. 32, No. 6, pp. 1272-1276 (1989).
E. J. Corey et al., "Studies on the Mechanism of Oxidation of Ketones by Selenium Dioxide (Part I)," J. Am. Chem. Soc., vol. 82, pp. 918-929 (1960).
T. S. Lin et al., "Synthesis of 2,3-Diaziridinyl-1,4-Naphthoquinone Sulfonate Derivatives as Potential Antineoplastic Agents," J. Med. Chem., vol. 32, No. 7, pp. 1467-1471 (1989).
A. C. Sartorelli et al., "Mechanism of Inhibition of Ribonucleoside Diphosphate Reductase by .alpha.-(N)-Heterocyclic Aldehyde Thiosemicarbazones," Biochem. Pharmacol., vol. 20, pp. 3119-3123 (1971).
Wang et al., "Synthesis and Antitumor Activity of 3- and 5-Hydroxy-4-Methylpyridine-2-Carboxaldehyde Thiosemicarbazones," Journal of Medicinal Chemistry, vol. 35, No. 20, pp. 3667-3671, Oct. 2, 1992.
Liu et al., "Synthesis and Antitumor Activity of Amino Derivatives of Pyridine-2-Carboxaldehyde Thiosemicarbazone," Journal of Medicinal Chemistry, vol. 35, No. 20, pp. 3672-3677, Oct. 2, 1992.
Blanz et al., "Carcinostatic Activity of Thiosemicarbazones of Formyl Heteroaromatic Compounds. VII. 2-Formylpyridine Derivatives Bearing Additional Ring Substituents," Journal of Medicinal Chemistry, vol. 13, No. 6, pp. 1124-1130, Nov. 1970; and Chem. Abstracts, vol. 74, No. 3, Abstract No. 11774j, Jan. 18, 1971.
Chemical Abstracts, vol. 104, No. 5, Abstract 28370k, p. 13, Feb. 3, 1986.

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