Process for the preparation of cis-5-fluoro-2-methyl-1-(4-methyl

Details Process for the preparation of cis-5-fluoro-2-methyl-1-(4-methyl Process for the preparation of cis-5-fluoro-2-methyl-1-(4-methyl

1986-06-17

1988-05-31

Moyer, Donald B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562429, C07C147107, C07C14711

Patent

active

047482710

ABSTRACT:
A process is described for the preparation of cis-5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-indene-3-acetic acid that consists in reacting a lower alkyl ester of 5-fluoro-2-methylindene-3-acetic acid with a substantially equimolecular amount of 4-methylthio-benzaldehyde in a solid-liquid two-phase system in which the solid phase is a potassium alcoholate or hydroxide and the liquid phase is a solution of the reagents in an organic solvent inert in the reaction conditions, in the presence of a phase transfer catalyst and at a temperature comprised between -20.degree. and +20.degree. C.

REFERENCES:
patent: 3692651 (1972-09-01), Sletzinger
patent: 3766259 (1973-10-01), Sletzinger et al.
patent: 3932498 (1976-01-01), Shen et al.
Shuman et al., Journal of Organic Chemistry, vol. 42, No. 11, 1977, pp. 1914-1919.

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