Substituted alpha-[2'-tricyclo[3.3.1.1.sup.3,7 ]-decylidene]benz

Details Substituted alpha-[2'-tricyclo[3.3.1.1.sup.3,7 ]-decylidene]benz Substituted alpha-[2'-tricyclo[3.3.1.1.sup.3,7 ]-decylidene]benz

1986-05-27

1988-05-31

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C07C12168

Patent

active

047482648

ABSTRACT:
Substituted .alpha.-[2'-tricyclo[3.3.1.1.sup.3,7 ]decylidene]benzeneacetonitrile derivatives having antihypoxia and anti-inflammatory activities of the formula: ##STR1## where the R.sup.1, R.sup.2 and R.sup.3 substituents are independently selected from hydrogen, lower alkyl, lower alkoxy, halogen and trifluoromethane, provided that at least one of such substituents is hydrogen.

REFERENCES:
patent: 3624126 (1971-11-01), Narayanan
CA 89:123330c, Jap. 78 19665, Yoshiaki et al., 6/22/78, "Adamantane-1-acetonitrile . . . ".
Aigami et al., "Biologically Active Polycycloalkanes.1, Antiviral Adamantane Derivatives", J. Med. Chem. 18, 713-721 (1975).
Lundahl et al., "Synthesis and Antiviral Activities of Adamantane Spiro Compounds I", J. Med. Chem. 15, 129-132 (1972).
Gaspert et al., "Synthesis of .alpha.-Amino-1-Adamantylacetic . . . Acid", Croat Chim. Acta. 48, p. 169 (1976).
Van Hes et al., "Synthesis and Antiviral Activities of Adamantane Spiro Compounds. 2", J. Med. Chem. 15, 132-136 (1972).

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