Substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids

Details Substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids Substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids

1987-01-28

1988-05-31

Ceperley, Mary E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548495, 548507, C07D49304

Patent

active

047482524

ABSTRACT:
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at position 8. The derivatives are useful anti-inflammatory and analgesic agents and methods and chemical intermediates for their preparation are also disclosed.

REFERENCES:
patent: 3843681 (1974-10-01), Demerson et al.
patent: 3939178 (1976-02-01), Demerson et al.
patent: 3974179 (1976-08-01), Demerson et al.
patent: 4585877 (1986-04-01), Demerson et al.
M. Cayen et al., Chem. Abstracts, vol. 96, No. 170n (1982), The Metabolic Disposition of Etodolac in Rats, Dogs and Man.
C. Demerson et al., J. Med. Chem., 18, 189 (1975).

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