Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-03-20
1998-02-24
Walsh, Stephen
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 604 51, 128898, A61K 3816, A61M 1300
Patent
active
057212155
ABSTRACT:
A method for administration of botulinum toxin, includes the steps of (a) selecting at least one neuromuscular blocking agent having a duration of activity shorter than neuromuscular blocking activity of botulinum toxin; (b) selecting at least one muscle of a muscle group; (c) intramuscularly injecting the selected agent into the selected muscle; (d) observing muscle relaxation in both the selected muscle and other nonselected muscles in the muscle group to determine spill-over, muscle tone and balance; (e) repeating steps (b)-(d) until a final muscle selection is found; and (f) intramuscularly injecting botulinum toxin into the final muscle selection.
REFERENCES:
patent: 5401243 (1995-03-01), Borodic
Doggrell Journal of Pharmaceutical Methods vol 10(4): pp. 243-254 (1983).
Ishikawa et al Brain Research vol 346(1): pp. 82-88 (1985).
Aoki Kei Roger
Garst Michael E.
Wheeler Larry A.
Allergan
Basham Daryl A.
Hackler Walter A.
Walsh Stephen
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