Methods and compositions useful in the diagnosis and treatment o

Details Methods and compositions useful in the diagnosis and treatment o Methods and compositions useful in the diagnosis and treatment o

1994-09-02

1998-02-24

Knode, Marian C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

436518, 436506, 436508, 436811, 935110, G01N 33531, G01N 33543, G01N 33564, C12N 1512

Patent

active

057211108

ABSTRACT:
A method for producing a protein antigen which is reactive with an autoantibody associated with an autoimmune disease in a host, which comprises introducing genetic information from a cross-reactive donor gene library, into plural cells thereby producing transformed cells; selecting a producer cell which expresses said antigen by detecting a binding reaction between said autoantibody obtained from said host and a protein antigen expressed by a producer cell of said transformed cells which contains a gene coding for said protein antigen, thereby identifying a cloned DNA segment from said donor which can be utilized in the production of said protein, is disclosed along with biochemical reagents and products associated with this invention.

REFERENCES:
patent: 4751181 (1988-06-01), Keene

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