Thrombin-binding substance and process for preparing the same

Details Thrombin-binding substance and process for preparing the same Thrombin-binding substance and process for preparing the same

1987-01-15

1988-05-31

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 424 85, 424105, 530350, 530413, 530419, 530399, C07K 320, C07K 328

Patent

active

047481560

ABSTRACT:
A novel thrombin-binding substance having the characteristics of (a) molecular weight: 47,000.+-.6,000 in reduced condition and 38,000.+-.6,000 in unreduced condition, (b) isoelectric point: pH 4.9-5.7, (c) affinity: strong affinity to thrombin, (d) activity: (1) capable of promoting the thrombin catalyzed activation of protein C, (2) prolongs clotting time; and (e) stability: stable to denaturing agents (urea sodium and dodecylsulfate), can be prepared from a human placenta by means of extraction, fractionation using ion exchange chromatography and affinity chromatography, and/or gel filtration, followed by electrophoresis. The substance is useful as a medicine for the treatment of thrombosis.

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Thromb. Res. 37, 353-364 (1985), Esmon et al.
J. Clin. Invest. 75, 987-991, (Mar. 1985), Maruyama et al.

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