Mutagenicity assay

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...

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435 29, 435172, 435 6, C12Q 100

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043450261

ABSTRACT:
Mutagenicity assay method involving exposing a population of an animal species to a suspected mutagen and then scoring the occurrence, in a subsequent generation, of animals of a size substantially different from that of the exposed population as a measure of the mutagenicity of the suspected mutagen.

REFERENCES:
patent: 3816263 (1974-06-01), Rabin et al.
patent: 4066510 (1978-01-01), Thilly
patent: 4072574 (1978-02-01), Loeb et al.
Ames et al., "Carcinogens are Mutagens: A Simple System Combining Liver Homogenates for Activation and Bacteria for Detection", Proc. Nat. Acad. Sci. USA., vol. 7, No. 8, (Aug. 1973), pp. 2281-2285.
Ames et al., "Methods for Detecting Carcinogens and Mutagens with the Salmonella/Mammalian-Microsome Mutagencity Test", Mutation Research, 31, (1975), pp. 347-364.
Cedric I. Davern, Genetics, Readings from Scientific American, pp. 2-17, 1979.

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