N-heteroarenesulfonyl-protected amino acid reagents for peptide

Details N-heteroarenesulfonyl-protected amino acid reagents for peptide N-heteroarenesulfonyl-protected amino acid reagents for peptide

1996-05-03

1999-05-04

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514376, 514369, 514375, 548166, 548221, 548186, 548229, A61K 31425, C07D27776

Patent

active

059004274

ABSTRACT:
This invention relates to the use of heteroarenesulfonyl groups as protecting groups for amino groups, particularly the amino groups of amino acids, and specifically to nitrogen-protected (N-protected) amino acid reagents, which are particularly well-suited for use in peptide syntheses. In particular, the N-protected amino acid reagent is an N-heteroarenesulfonyl-protected amino acid halide. The heteroarenesulfonyl protecting groups are readily removed under relatively mild conditions.

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