Aqueous caffeine dosage forms

Details Aqueous caffeine dosage forms Aqueous caffeine dosage forms

1996-02-01

1999-05-04

Cook, Rebecca

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A01N 4390

Patent

active

059004169

ABSTRACT:
Aqueous caffeine solutions containing a co-solubilizing agent selected from niacinamide, nicotinic acid and mixtures thereof present at a level up to the maximum concentration soluble in water and in a weight ratio to caffeine less than 1.50:1, wherein the caffeine is present up to the maximum level between about 2 and about 20 percent by weight that is water-soluble in combination with the co-solubilizing agent and the solution is buffered to a pH less than about 6. Methods for preparing the aqueous caffeine solutions of the present invention are also disclosed.

REFERENCES:
patent: 4076856 (1978-02-01), Zeitlin
CA 85: 130513, Klosa, Jul. 1, 1976.
CA 84: 49816, Klosa, Nov. 27, 1974.
Merck 10th edition, entries 6329 and 6366, 1983.
CA 107 :54012 Blass, 1977.
CA 81: 158677 Rice, 1974.
CA 87: 106752, Klossa, 1977.
WP 86-149191, Budnikou, 1985.
WP 82-13420E, Salvanova, 1981.

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