Use of antibiotics of the type 2-deoxystreptamine substituted wi

Details Use of antibiotics of the type 2-deoxystreptamine substituted wi Use of antibiotics of the type 2-deoxystreptamine substituted wi

1994-06-08

1999-05-04

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 36, 514 37, 514 38, 514 39, 514 40, 514 41, A61K 3170

Patent

active

059004061

ABSTRACT:
The invention described herein provides for methods of screening for compounds that can be used to prevent or inhibit the growth of microbial eukaryotes, particularly plant or animal pathogens. The screening methods of the invention involve the step of screening compounds for the ability to inhibit Group I intron I splicing. In addition, to directly screening for compounds that inhibit Group I intron splicing, the screening methods of the invention include screening for compounds that bind to prokaryotic 16S ribosomal RNA because of the correlation, described herein, between group I intron inhibition and binding to prokaryotic 16S ribosomal RNA. The range of possible compounds for screening by the screening methods of the invention is preferably limited to 2-deoxystreptamine derivatives.
Another aspect of the invention is to provide methods of treating or preventing infections with eukaryotic microbes by administering an effective amount of a compound that inhibits group I intron splicing. These compounds may be obtained by the screening methods of the invention.

REFERENCES:
patent: 2501014 (1950-03-01), Wintersteiner et al.
patent: 2931798 (1960-04-01), Umezana et al.
patent: 3976768 (1976-08-01), Nara et al.
patent: 4029883 (1977-06-01), Hiraga et al.

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