Process for preparing pyridine-2-carboxamides

Details Process for preparing pyridine-2-carboxamides Process for preparing pyridine-2-carboxamides

1994-09-12

1996-07-09

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546318, 546327, C07D21381, C07D21356

Patent

active

055346359

ABSTRACT:
It has been found that pyridine-2-carboxamides of the formula ##STR1## wherein R is amino or a residue convertible into amino, and pharmaceutically usable acid addition salts of that carboxamide in which R is amino can be prepared in a simple manner and in good yield by reacting 2,5-dichloropyridine in the presence of a palladium-phosphine catalyst with an alkyne of the formula

REFERENCES:
patent: 2749350 (1956-06-01), Nowlin
patent: 3862159 (1975-01-01), Umezawa et al.
patent: 4764522 (1988-08-01), Imhof et al.
Tilley, et al., J. Org. Chem. 53,386 (1988).
Sakamoto, et al., Chem. Pharm. Bull. 36,1890 (1988).
Sonogashira, et al., Tetrahedron Letters, 50, 4467 (1975).
Lee, et al., J. Org. Chem. 44, 2726 (1979).
Chem. Abstrs. vol. 95(9) Abstr. No. 80892-S Aug. 31, 1981.
Chem. Abstrs. vol. 99(7) Abstr. No. 53 823-W Aug. 15, 1983.
Chem. Abstr. vol. 73(25) Abstr. No. 130 851-W, Dec. 21, 1970.
Chem. Abstr. vol. 105(11) Abstr. No. 97 323e, Sep. 15, 1986.
Chem. Abstr. vol. 109(25) Abstr. No. 231 063h, Dec. 19, 1988.
R. F. Heck, Palladium Reagents In Organic Synthesis, Academic Press (1985) pp. 299-306, 348-362.
Sakamoto, et al., Palladium (o)-Catalyzed Condensation of Bromopyridines With .alpha.-Substituted Acetonitriles, Heterocycles, 27(6) 1353 (1988).

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