Process for the preparation of carbofuran

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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549462, 568377, C07D30786, C07D 49603

Patent

active

044631847

ABSTRACT:
A novel process is provided for the preparation of carbofuran and certain intermediate products. 1,2-Cyclohexanedione is alkylated with a beta-methallyl compound and the resulting product subjected to a Claisen rearrangement/aromatization to provide the carbofuran phenol. Reaction of the phenol with methyl isocyanate converts the phenol to the desired carbofuran.

REFERENCES:
patent: 3320286 (1967-05-01), Franko-Filipasic
Tamura et al., Chemical and Pharmaceutical Bulletin, vol. 19(3), pp. 571-575 (1971).

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