Selected 3-acylamino-5-[4(or 3)-pyridinyl]-2(1H)-pyridinones

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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546257, A61K 3144, C07D21357

Patent

active

042711681

ABSTRACT:
3-Acylamino-5-[4(or 3)-pyridinyl]-2(1H)-pyridinones or pharmaceutically-acceptable acid-addition salts thereof useful as cardiotonic agents are prepared by reacting the corresponding 3-amino compound with an acylating agent providing acyl, where acyl is 2-acetoxypropanoyl, acetoacetyl or acetoxyacetyl. Cardiotonic compositions and method for increasing cardiac contractility using said 3-acylamino compounds as active component are disclosed.

REFERENCES:
patent: 4004012 (1977-01-01), Lesher et al.
patent: 4072746 (1978-02-01), Lesher et al.
patent: 4107315 (1978-08-01), Lesher et al.

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