7-N-Heterocyclyl-2-substituted 1-oxadethia-cephalosporins

Details 7-N-Heterocyclyl-2-substituted 1-oxadethia-cephalosporins 7-N-Heterocyclyl-2-substituted 1-oxadethia-cephalosporins

1979-08-01

1981-06-02

Randolph, John D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424853, 424256, 544 90, 546 13, 546283, 546341, 546345, 546347, A61K 3144, C07D49800, A61K 3147, A61K 31535

Patent

active

042711592

ABSTRACT:
Disclosed are antibiotic cephalosporins (I) of the formula: ##STR1## Wherein the stylized radical attached to the 7-amino nitrogen of the cephalosporin moiety represents a nitrogen-containing heterocyclic group (mono- or polycyclic); R is, inter alia, hydrogen, alkyl, heterocyclylalkyl, aryl, alkenyl, aralkyl, --NR.sub.2, --OR, COOR, CONR.sub.2 or CN; R.sup.o is H or CH.sub.3 ; and R.sup.2 is H, or loweralkoxyl: Also disclosed are the pharmaceutically acceptable salt and ester derivatives of I; processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

REFERENCES:
Degering, An Outline of Organic Chemistry, 6th Ed., p. 142, Barnes & Noble, Inc., NY, (1951).

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