Compositions and method of treating arrythmia with tetrahydropyr

Details Compositions and method of treating arrythmia with tetrahydropyr Compositions and method of treating arrythmia with tetrahydropyr

1990-03-06

1992-06-30

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, 514314, H61K 31505, H61K 31435, H61K 3147

Patent

active

051263530

ABSTRACT:
Novel enantiomeric and diasteroisomeric forms of tetrahydropyridines of the formula ##STR1## wherein n.sub.1 is 0 or 2, A is selected from the group consisting of --(CH.sub.2).sub.n2 -- and alkylene substituted with alkyl having a total of 2 to 8 carbon atoms and n.sub.2 is 0 to 5, Z is selected from the group consisting of phenyl, naphthyl, indenyl, heteromonocycle of 5 to 6 ring members and heterobicycle, each optionally substituted with at least one substituent and their non-toxic, pharmaceutically acceptable acid addition salts and quarternary ammonium salts having central analgesic properties as well as diuretic, anti-arrhythmic, anti-cerebral-ischemia and hypotensive properties.

REFERENCES:
patent: 4927832 (1990-05-01), Clemence et al.

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