Preparation of 2-hydroxyalkylchromans

Details Preparation of 2-hydroxyalkylchromans Preparation of 2-hydroxyalkylchromans

1981-02-26

1982-08-17

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31172

Patent

active

043448860

ABSTRACT:
2-Hydroxyalkylchromans (I) ##STR1## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each H or C.sub.1 -C.sub.8 -alkyl, R' is H or an organic radical which can be split off hydrolytically or hydrogenolytically as R'-OH or R'-COOH, and m is 1, 2 or 3, are prepared by reacting a hydroquinone II ##STR2## (a) with an alkenediol IIIa ##STR3## or (b) with an alkenediol IIIb ##STR4## or (c) with an alkenediol IIIc ##STR5## where R.sup.4' is a radical which during the condensation with II is converted to the radical R.sup.4,
at from -50.degree. C. to 120.degree. C., in an inert solvent, in the presence of from 10 to 300 mole %, based on II, of a Lewis acid or of an adduct of a Lewis acid with a Lewis base which has a lower basicity than compound II.

REFERENCES:
patent: 2411969 (1946-12-01), Karrer et al.
patent: 3444213 (1969-05-01), Nelan
patent: 4026907 (1977-05-01), Scott et al.
patent: 4191692 (1980-03-01), Grafen et al.

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