Thrombomodulin-coated bicompatible substance

Details Thrombomodulin-coated bicompatible substance Thrombomodulin-coated bicompatible substance

1989-07-24

1992-06-30

Page, Thurman

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424422, 424424, 424425, 424426, 523112, 523113, 530395, 6048901, A61F 200, A61K 922

Patent

active

051261405

ABSTRACT:
Disclosed is a biocompatible, thromboresistant substance useful for implantable and extracorporeal devices in contact with the vascular system, and methods for producing the same. The biocompatible, thromboresistant substance comprises a synthetic, biocompatible material, at least one biocompatible base coat layer adhered to at least one surface of the material, and the thrombogenesis inhibitor thrombomodulin immobilized on the base coat layer via a component capable of binding the inhibitor without affecting its thrombogenesis-inhibiting activity.

REFERENCES:
patent: 4116898 (1978-09-01), Dudley et al.
patent: 4600652 (1986-07-01), Solomon et al.
patent: 4720512 (1988-01-01), Hu et al.

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