Process for the preparation of an antiviral agent

Details Process for the preparation of an antiviral agent Process for the preparation of an antiviral agent

1996-09-13

1998-06-30

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

544277, 556436, 560106, 560123, 549342, 568329, C07D47318, C07D47340, C07C 6978, C07C 49753

Patent

active

057736146

ABSTRACT:
(1R,trans) Diprotected 3-methylene-1,2-cyclopropanedimethanol is oxidized to an optically active diol ##STR1## which is then cyclized to an orthoester ##STR2## This orthoester is then treated with a Lewis acid catalyst to give the cyclobutanone ##STR3## which is useful as an intermediate in the preparation of the antiviral agent yl!-1,9-dihydro-6H-purin-6-one.

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