Coded thin layer chromatography support

Details Coded thin layer chromatography support Coded thin layer chromatography support

1996-05-15

1998-06-30

Ludlow, Jan

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Means for analyzing liquid or solid sample

73 6154, 2101983, 210658, 422 56, 422 57, 436162, 347225, G01N 3090

Patent

active

057735760

DESCRIPTION:

BRIEF SUMMARY
The invention relates to a coded support for thin layer chromatography ("TLC") and to a process for its production.
The developments on modern analysis methods are ever increasing, for example with regard to accuracy, reproducibility, unambiguous assignment and documentation of analysis results. Thus, the increasing demands for documentation have been met, for example, in guidelines such as DIN-ISO 9000, Good Manufacturing Practice (GMP) or Good Laboratory Practice (GLP).
It is correspondingly necessary to individually mark or code even ready-prepared layers in TLC during and after their chromatographic use, and therefore make them impossible to mistake for each other.
Such a marking should have the highest possible information density and be capable of being applied quickly onto or into the respective layer. Above all, however, it should be resistant to all organic and inorganic solvents, bases and acids (not only in liquid form, but also in the case of gas-phase action as a result of vaporization) which are conventionally used in TLC so that neither the chromatographic development nor the result of the separation is disrupted or affected. In addition, the marking should be readable not only in daylight but also under UV illumination (for example 254 and 366 nm).
The markings conventionally used to date, for example by sticking on labels or inscriptions in the carrier layer, satisfy these requirements only partially or not at all, and are also laborious. As a result of manual data transfer, transfer errors can make the entries unusable. Labels can become detached and be lost.
The object of the invention was to provide marked (coded) TLC supports which present the specified disadvantages not at all or only to a lesser extent.
It was surprisingly found that the intended result can be achieved by exposing the support to laser light, a corresponding template being used (for example numbers and/or letters or else lines for bar coding) or the laser being controlled by means of a computer. This produces a permanent mark which is easy to read in daylight and under UV light. When the laser is controlled by means of a computer, no templates are required.
The subject of the invention is correspondingly a TLC support characterized by a coding applied by means of laser light, and a process for its production, characterized in that a conventional TLC support is exposed to laser light.
Supports are primarily glass plates and foils (for example aluminum foils or plastic films, for example those made of polyterephthalate), which are coated with sorbent and contain a binder as well as, optionally, a fluorescent indicator and/or further additives.
All stationary phases conventionally used in TLC are suitable as sorbents, preferably modified or unmodified silica gels, as well as, for example, celluloses, polyamides, diatomaceous earth, aluminum oxides.
Polymeric organic substances are preferably used as binders, for example polyacrylic acid or polymethacrylic acid, and amides thereof.
A pulsed or continuous CO.sub.2 laser (wavelength 1.06 .mu.m) or a Yag laser (solid-state laser, wavelength 10.6 .mu.m) is preferably used as the laser source. The exposure time is typically equal to 5-50 nanoseconds per symbol.
The coding obtained may contain any data, for example logo of the producer company, item number, batch number, date of production, unique individual numbering (serial numbering).
Coding is preferably carried out by exposing the sorbent layer, which contains a binder. It is, however, also possible to make a laser inscription on the uncoated back of a support glass plate or a coated plastic film. In the case of a glass plate, the exposure produces fine thermal stress cracks which causes opaqueness of the glass surface that can be discerned in the visible light wavelength range.
Even without further comments, it will be assumed that a person skilled in the art can use the above description in the widest scope. The preferred exemplary embodiments should therefore be taken merely by way of description, without any limitation

REFERENCES:
patent: 4126554 (1978-11-01), Rainin
patent: 4960691 (1990-10-01), Gordon et al.
Pfeufer et al., Kunstoffe vol. 79 No. 6 issued Jun. 1989 pp. L43-L46.

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