Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 11 to 14 amino acid residues in defined sequence
Patent
1995-06-05
1998-06-30
Smith, Lynette F.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
11 to 14 amino acid residues in defined sequence
530326, 530325, 530324, 4242081, 4241841, 4241881, A61K 3804, A61K 3921, A61K 3938, C07K 500
Patent
active
057735735
ABSTRACT:
It is an object of the present invention to provide preparations for the treatment or prophylaxis of AIDS and systemic lupus erythematosus and related disorders. The invention is based on the discovery of the process triggered in the immune system by HIV which leads to AIDS. HIV has a specific mechanism to activate the immune system to allow it to replicate and this same immune activation leads to an autoimmune process which eventually leads to AIDS. The preparation for treatment comprises novel synthesized peptides whose amino acid sequences are derived from a human protein called ezrin and are based on the following sequence: NH.sub.2 ThrGluLysLysArgArgGluThrValGluArgGluLysGluCOOH SEQ ID. No. 2. The mechanism of action of these peptides is that they switch off specific retrovirally induced immune responses by immunological tolerance.
REFERENCES:
Araga, S. et al. (1993) "Prevention of experimental autoimmune myasthenia gravis by manipulation of the immune network with a complementary peptide for the acetylcholine receptor" Proc. Natl. Acad. Sci. USA 90:8747-8751.
Egerton, M. et al. (1992) "Identification of Ezrin as an 81-kDa Tyrpsine-phosphorylated Protein in T Cells" The Journal of Immunology 149:1847-1852.
Krieg, J., T. Hunter (1992) "Identification of the Two Major Epidermal Growth Factor-induced Tyrosine Phosphorylation Sites in the Microvillar Core Protein Ezrin" The Journal of Biological Chemistry 267(27):19258-19265.
Briner, T.J. et al. (1993) "Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d l" Proc. Natl. Acad. Sci. USA 90:7608-7612.
Stephen, H. et al. (1990) "Could specific oral tolerance be a therapy for autoimmune disease?" Immunology Today 11(11):396-399.
Sayegh, M.H. et al. (1992) "Induction of immunity and oral tolerance with polymorphic class II major histocompatibility complex allopeptides in the rat" Proc. Natl. Acad. Sci. USA 89:7762-7766.
Whitacre, C.C. et al. (1991) "Oral Tolerance in Experimental Autoimmune Encephalomyelitis III. Evidence for Clonal Anergy" The Journal of Immunology 147(7):2155-2163.
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