Method of preparing a synergistic immunological adjuvant formula

Drug – bio-affecting and body treating compositions – Nonspecific immunoeffector – per se ; or nonspecific...

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424614, 424724, 424719, 424600, 424622, 424630, 424689, 514494, 514499, A61K 4500, A61K 3130, A01N 5906, A01N 5502

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057730113

ABSTRACT:
The improved method uses N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) or N-acetylglucosaminyl-N-acetyl-muramyl-L-alanyl-D-isoglutamine (GMDP) in low dose ranges in a combination with zinc-L-proline complex and with immunostimulating lipid in doses which synergistically potentiate the effect of each single component whereby the zinc-L-proline complex contains an excess of L-proline or 5-oxo-L-proline which serves as a solubiliser and dispersing agent for the lipid component.

REFERENCES:
patent: 4036953 (1977-07-01), Adam et al.
patent: 4094971 (1978-06-01), Chedid et al.
patent: 4395399 (1983-07-01), Ovchinnikov et al.
patent: 4578269 (1986-03-01), Merein
patent: 4801578 (1989-01-01), Monsigny et al.
patent: 4845042 (1989-07-01), Newman et al.
patent: 4877612 (1989-10-01), Berger et al.
patent: 5109026 (1992-04-01), Hoskinson et al.
patent: 5376369 (1994-12-01), Allison et al.
patent: 5409698 (1995-04-01), Anderson et al.
Byars, Noelene E., et al. (1987) "Adjuvant formulation for use in vaccines to elicit both cell-mediated and humor immunity ", Vaccine, 5:223-228.
Grubhofer, N. (1995) "An adjuvant formulation based on N-acetylglucosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutamine with dimethyldioctadecylammonium chloride and zinc-L-proline complex as synergists ", Immunology Letters, 44:19-24.
Vogel, F.R., et al. (1995) "A Compendium of Vaccine Adjuvants and Excipients ", in: Vaccine Design, M.F. Powell & M.J. Newman Eds. Plenum publishing Corp NY in press.
Hilgers et al, Cellular Immunol. 90:14-23, 1985.
Hilgers et al, Cellular Immunol. 86:393-401, 1984.
Hilgers et al, Cellular Immunol, 92:203-209, 1985
Hilgers et al, Int. Archs. Allerg. Appl. Immunol. 79:388-391, 1986.
Woodard et al. Inf & Imm. 30 (2): 409-412, 1980.
Arakawa et al 1993. Adv. Drug Delivery Rev. 10 : 1-28.
Flosdorf et al 1935. J. Immumol. 29 : 389-425.
Hilgers et al 1986 Int. Archs. Allergy Appl Immunol 79 : 392-96.
Nesmeyanov et al. 1990 Biomedical Science 1(2) : 151-154.
Abeshira-Amer et al 1987 Mol. Immunol 24(9):945-51.
Nash et al, 1985. J. Reprod. Immunol. 7:151-162.
Sharma et al, 1988 Tech. Adv. in Vacc. Dev. pp 107-116.
Shimizu et al 1992. Int. Immunopharm. 14(8):1415-20.
Audibert et al, 1977, Ann. Immunol 128C: 653-61.
Andronova et al, 1991. Sov. Med. Rev. D. Immunol. 4: 1-63.
Auci et al 1993, Int. Arch. Allergy Immunol, 101: 167-176.
Khullar et al, 1988. Immunol Invest. 17(1): 1-17.
Ott et al, 1995. In: Vaccine Design: The subunit and Adjuvant Approach Ed.
Powell et al. Plenum Press NY pp. 277-295 Bomford 1992. Med. Virol. 2:169-174.
Carelli et al. 1981, Inf & Imm. 33(1) : 312-314.
Alam et al, 1991 Immunol Lett. 27: 53-58.
Teerlink et al, 1987, Vaccine 5 :307-314.
Edelman et al, 1990, Intern. Rev. Immunol.7:51-66.
Grubhofer et al 1993. In: Animal Cell Technology: Basic&Applied Aspects, vol. 5:557-564. Eds: Kaminogawa et al.
Hilgers et al, 1992. Res. Immunol, 143:494-503.
Grubhofer et al, 1994, FASEBJ. 8(4-5): A993.
Allison et al 1988 Tech. Adv. Vacc. Dev. pp. 401-409.
Bennett et al, 1992. J. Immunol Methods. 153:31-40.
Tsujimoto et al, 1986, Inf&Imm. 53(3) : 511-516.
Allison et al, 1986, J. Immunol, Methods, 95:157-168.
Gregeriadis et al 1989. Immunol Lett. 20:237-240.
Yin et al 1989. J. Biological Resp. Modifiers 8:190-205.
Esher et al, 1974, J. Nat'l Cancer Institute 53(1):209-212.
Desowitz et al, et al, 1980. Inf & Imm. 27(1): 87-89.
Wong et al, 1976, Int. Arch Allergy Appl. Imm. 50:155-163.
Dzata et al, 1991, Vet. Microbiol, 29:15-26.
Audibert et al, 1984, Inf. Imm. 45(1):261-66.
Richards et al, 1988, Inf. & Imm. 56(3):682-686.
Warren et al, 1986, Ann. Rev. Immunol. 4:369-88.
Stanfield et al 1973. The Lancet 3 Feb 1973 pp. 215-219.

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