Thioetianic acid derivatives

Details Thioetianic acid derivatives Thioetianic acid derivatives

1978-04-05

1980-02-12

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

26023955D, 424243, A61K 3158, C07J 7100

Patent

active

041883853

ABSTRACT:
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters are useful as antiinflammatory steroids. These compounds are optionally substituted at the 6 alpha-position with fluoro, or chloro; optionally substituted at the 9 alpha position with fluoro, chloro or bromo; substituted at the 11 position with a keto, a beta-hydroxy on a beta-chloro (the latter only when there is a 9 alpha-chloro); substituted at 16 alpha, 17 alpha-positions with isopropylidenedioxy; and substituted at 16 alpha (or 16 beta) with methyl or hydrogen when there is a 17 alpha-hydroxy (or an ester).

REFERENCES:
patent: 3856828 (1974-12-01), Phillipps et al.
patent: 3989686 (1976-11-01), Phillipps et al.

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