Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1996-03-27
1998-06-30
Buiz, Michael
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
604 89, 604191, A61M 3700
Patent
active
057726302
DESCRIPTION:
BRIEF SUMMARY
The present invention refers to an improvement in injection cartridges for administering parenteral injections or infusions. More particularly, the invention refers to an improvement in such injection cartridges which makes possible a better utilization of the injectable preparation used. The invention also refers to a method for administering a liquid preparation with the use of an injection cartridge of the invention. Furthermore, the invention also refers to the use of an injection cartridge of the invention for intravenous injection.
Injection cartridges have found a wide use for administering injectable pharmaceutical preparations by means of parenteral injection or infusion. Such cartridges have a number of important advantages, such as their ease of handling and the lessened risk of microbial contamination. An injection cartridge generally comprises a tubular barrel, which contains a liquid injectable preparation. At its front end, the barrel is sealed by a closure, which may be pierced by an outlet conduit, such as an injection needle or cannula or a tube for infusion. At its rear end, the cartridge is closed by a piston, which may be moved forward to expel the injectable preparation from the cartridge through the outlet conduit. This type of injection cartridge is known as a single-chamber injection cartridge.
Dual-chamber injection cartridges are also well-known. Such cartridges are intended to be used for injectable preparations which are not stable in their ready-to-use state, and their space between the front closure and the rear piston is divided into two chambers, which are separated by a movable wall. The front chamber usually contains a solid component of the injectable preparation, and the rear chamber contains a liquid component of said preparation. At a predetermined position in the cartridge, there is arranged a liquid bypass connection in the interior wall of the cartridge, such that the liquid component may bypass the movable separating wall and flow into the front chamber to be mixed with the solid component. When a forwardly directed pressure is applied to the rear piston, this pressure will be translated through the liquid to urge the movable wall forward, and when this wall is at the position of the bypass connection, the liquid will flow around said wall to be mixed with the component in the front chamber. In this way, the two components may be mixed with each other just before the injection is to be administered, and there will be no time for degradation of the ready-mixed preparation. When all the liquid has been transferred to the front chamber, the rear piston will abut the movable wall, and on further movement forward they will act as a single piston for expelling the mixed preparation from the cartridge.
U.S. Pat. No. 4,439,184 discloses a two-dose syringe with a dual chamber, intended to provide two separate bodies of fluid in a sequence. In the prefarred embodiment, a lubricating antiseptic and a lubricating anesthetic are used for preparing the urethra for catheterization. The lubricating properties of both the antiseptic and the anesthetic make it easier for the catheter to be slid into the urethra.
The design and function of single-chamber and dual-chamber injection cartridges is well-known to those skilled in the art, and need not be described here in closer detail.
When the administration of a liquid preparation from the injection cartridge has been finished and the rear piston is in its foremost position, there still exists a certain dead volume in front of the piston in the front end part and the outlet of the cartridge. This dead volume can be considerable, especially when a tube of some length is arranged between the outlet and the needle or cannula. This is a disadvantage, as it.means that a certain amount of the pharmaceutical preparation will not be utilized by the patient. The disadvantage is aggravated when very expensive pharmaceutical preparations are used, such as growth hormones and certain peptides.
Various ways have been tried to eliminate this disadv
REFERENCES:
patent: 4439184 (1984-03-01), Wheeler
patent: 5298024 (1994-03-01), Richmond
patent: 5476449 (1995-12-01), Richmond
patent: 5549569 (1996-08-01), Lynn et al.
Buiz Michael
Gring N. Kent
Pharmacia AB
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