Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-08-30
1998-05-19
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514255, 514327, 514357, 514394, 514399, 514406, 514427, 514428, 514429, 544392, 546221, 546332, 5483097, 5483361, 5483771, 548561, 548569, 548583, 549491, A61K 31445, C07D21144, C07D23364, C07D21368
Patent
active
057536805
ABSTRACT:
Heterocyclyl-benzoylguanidines of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and Het have the meanings given herein, and physiologically unobjectionable salts thereof, display antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.
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patent: 5461066 (1995-10-01), Gericke et al.
Schwark et al. "Preparation of Ureiodobenzoylguanidines as sodium-proton antiporter inhibitors" CA 123:55495d, 1995.
Weichert et al. "Preparation of ortho-substituted bonzoylguanidine sodium channel blocker"CA 123:55496c, 1995.
Kuno et al. "Guanidine derivatives as inhibitors of Na/H + exchange in cells"CA 123:256771a, 1995.
Baumgarth Manfred
Beier Norbert
Dorsch Dieter
Gericke Rolf
Minck Klaus-Otto
Chang Ceila
Merck Patent Gesellschaft mit beschrankter Haftung
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